Objective To study the relationship between elements of social relations and the certificate of ketamine addicts. Methods Drug abusers were diagnosed according to the criteria of DSM-IV substance dependence， and syndrome differentiation was collected. Results Ketamine and heroin addicts in work and learning effect existence difference Z values was -1.15**（P<0.05） and ketamine addiction in work， life and entertainment interests and spleen， stomach， heart and mind and wet related（P<0. 05）. Conclusion The effect of ketamine addicts key social relations was in the heart or mind dysfunction