Objective To observe the characteristics of evolution of syndrome elements of oxaliplatin in patients with colorectal cancer before and after chemotherapy in the process， and the therapy of traditional Chinese medicine and Western medicine to provide reference. Methods Collect 48 colorectal cancer patients received oxaliplatin hemotherapy with TCM diagnostic information， use syndrome elements differentiation to get the syndrome elements， observe the clinical symptoms and the changes of syndrome elements before and after chemotherapy. Results 48 cases of numbness， fatigue， loss of appetite decline in patients after chemotherapy， nausea and vomit an increase in the frequency of occurrence（P<0.05）， chemotherapy after disease of syndrome elements of yin deficiency， blood deficiency， Qi deficiency and disease syndrome spleen and kidney frequency significantly increased（P<0.05）. Conclusion The change of syndrome elements in patients with of colorectal cancer during chemotherapy， the main reason is the hemotherapy drugs on the human body， qi， blood and fluid damage， in which is the main cause of deficiency syndrome.