Objective To observe the effect of Qinzhu Liangxue mixture on eczema in peripheral blood of patients with GR receptor alpha. Methods A total of 60 cases of eczema were randomly divided into group A（32 cases） and group B（28 cases）. The patients in group A were treated with Qinzhu Liangxue decoction continuously for 4 weeks. Subjects in group B were treated with Mizolastine Sustained-release Tablets， twice a day continuously for 4 weeks. The content of GR receptor in the peripheral blood of the patients before and after treatment was detected， and compared with 20 healthy controls， which from the physical examination center of the Yueyang Hospital physical center. Results Two groups of eczema patients with peripheral blood GR receptor alpha， differences have significance（P<0.05）， compared with normal group， either Qinzhu Liangxue decoction in the treatment group（P <0.05）， however there is no significant difference between mizolastine group before and after treatment of peripheral blood GR alpha receptor content（P>0.05）. Conclusion Qinzhu Liangxue decoction can upregulation of eczema patients peripheral blood GR alpha content， the content of mizolastine in peripheral blood of patients with eczema and GR alpha no obvious change.