Objective To systematically review the efficacy and safety of aspirin combined kind of Chinese traditional medicine for activating blood circulation and removing stasis for aspirin resistance（AR）. Methods All the randomized controlled trials（RCTs） that used aspirin combined kind of Chinese traditional medicine for activating blood circulation and removing stasis and aspirin only for aspirin resistance（AR） were retrieved. Jadad score was used for quality evaluation. RevMan 5.3 was applied for analysis. Results Sis RCTs met the inclusion criteria. The result of meta-analysis showed in the terms of rate of the platelet aggregation induced by ADP， [SMD=-1.78， 95%（-2.95， -0.61）， P<0.003]， in the terms of rate of the platelet aggregation induced by AA， [SMD=-2.31， 95%（-3.41， -1.21）， P<0.0001]， in terms of the adverse reaction， [R=0.26， 95%（0.02， 3.13）， P>0.05]， and in terms of the endpoint of events， [R=0.26， 95%（0.05， 1.35）， P>0.05]. Conclusion The present meta-analysis suggests that combining kind of Chinese traditional medicine for activating blood circulation and removing stasis is helpful to reduce the platelet agggation rate and improve AR with reliable safety.