苓桂术甘汤治疗充血性心力衰竭随机对照试验之Meta分析
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北京中医药大学基础医学院,北京 100029

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R259

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基金项目: 2015北京中医药大学新奥基金
作者简介: 黄丽芳(1958-),女,广东潮阳人,在读博士研究生,新加坡注册执业中医师、针灸师,研究方向:《伤寒论》六经辨治规律研究。
通信作者:陈明,E-mail:cmwg185@sina.com


Meta Analysis Randomized Clinical Trials for Lingguizhugan Decoctionon the Treatment of Congestive Heart Failure
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School of Basic Medical Science, Beijing University of Chinese Medicine, Beijing 100029, China

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    摘要:

    目的 在具有相同研究内容及目的基础上将苓桂术甘汤及中西医结合治疗充血性心力衰竭的随机对照试验文献资料分类,共分为3组;采用RevMan基础Meta分析研究3组治疗充血性心力衰竭的疗效对比。方法 运用自1949年—2013年的3大数据库CNKI、CBM、VIP查检所需相关文献资料,全面筛选、整理符合苓桂术甘汤治疗充血性心力衰竭的随机对照试验之Meta分析评价的研究文献。然后使用RevMan5.2进行Meta-analysis处理3组苓桂术甘汤治疗充血性心力衰竭的疗效对比研究,包括OR、RR、RD等。结果 共纳入36篇临床随机对照研究文献,计733例患者,经Meta分析后得知组间较有显著性差异。其中,①苓桂术甘汤+西医三联疗法VS西医三联疗法:OR=3.54,95% CI为[1.92,6.56],Z检验=4.03,P<0.0001;RR=1.25,95%CI为[1.12,1.40],Z检验=4.07,P<0.0001;RD= -0.18,95%CI为[-0.26,-0.10],Z检验=4.36,P<0.0001。②苓桂术甘汤+西医四联疗法VS西医四联疗法:OR=4.83,95%CI为[1.51,15.41],Z检验=2.66,P=0.008;RR=1.16,95%CI为[1.04,1.30],Z检验=2.67,P=0.008;RD= -0.13,95%CI为[-0.23,-0.04],Z检验=2.81,P=0.005。③苓桂术甘汤+西医六联疗法VS西医六联疗法:OR=2.54,95%CI为[1.28,5.05],Z检验=2.67,P=0.007;RR=1.22,95%CI为[1.04,1.43],Z检验=2.49,P=0.01;RD=-0.15,95% CI为[-0.27,-0.004],Z检验=2.66,P=0.008。结论 苓桂术甘汤结合西药比单纯西药治疗充血性心力衰竭安全有效。

    Abstract:

    Objective Base on the same content and purpose, Lingguizhugan Decoction integrative treatment of congestive heart failure, randomized control trials data classification, which is divided into 3 groups. Finally, the use of Review Manager-based Meta-analysis to contrast the efficacy treatment for congestive heart failure. Methods Search of relevant documents is required and uses. From 1949—2013 three database CNKI, CBM, VIP. Comprehensive screening of randomized clinical trials and research literature on Lingguizhugan Decoction for treatment of congestive heart failure. Use of Meta-analysis, Comparison and studies on Lingguizhugan Decoction to treat Congestive Heart Failure including OR, RR, RD. Results A total of 36 randomized controlled clinical study of literature, on 733 cases of patients, after Meta-analysis showed a significant difference between the groups compared. Among them, (1) Lingguizhugan Decoction+Western triple therapy > Western triple therapy: OR=3.54, 95% CI=[1.92, 6.56], Z=4.03, P<0.0001; RR=1.25, 95% CI=[1.12, 1.40], Z=4.07, P<0.0001; RD=-0.18, 95% CI=[-0.26, -0.10], Z=4.36, P<0.0001。(2) Lingguizhugan Decoction+Western quadruple therapy>Western quadruple therapy: OR=4.83, 95% CI=[1.51, 15.41], Z=2.66, P=0.008; RR=1.16, 95% CI=[1.04, 1.30], Z=2.67, P=0.008; RD=-0.13, 95% CI=[-0.23, -0.04], Z=2.81, P=0.005。(3) Lingguizhugan Decoction+Western six combination therapy >Western six combination therapy: OR=2.54, 95% CI=[1.28, 5.05], Z=2.67, P=0.007; RR=1.22, 95% CI=[1.04, 1.43], Z=2.49, P=0.01; RD=-0.15, 95% CI=[-0.27, -0.004], Z=2.66, P=0.008. Conclusion From the above 3 statistical research groups, the best treatment result was obtained from the integrative medicine than with treatment using Western medicine alone.

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