Objective To evaluate qi and systemic evaluation on the immune function of patients with middle-late stage lung cancer. Methods To retrieve the 2005 to 2014 Chinese biomedical literature database， China journal full-text database and VIP journals database， a database of ten thousand published literature， and collect traditional Chinese medicine yiqi yangyin methond and chemotherapy treatment of advanced lung cancer randomised controlled trial（RCT）. According to the inclusion， exclusion criteria screening test， scored by using the improved Jadad method， extracted available data， then we used the Stata software for statistical analysis. Results In the end we selected 9 RCT studies， meta-analysis comparing between groups， according to the baseline of CD3+， CD4+， CD4+/CD8+ comparison of P>0.05（0.630， 0.480， 0.067 respectively）， and CD8+ P<0.001. Combined with yiqi yangyin Chinese traditional medicine after the intervention of CD3+， CD4+， CD4+/CD8+ P<0.05（<0.001， 0.009， <0.001 respectively）， and CD8+ P value is 0.562. Conclusion Yiqi Yangyin Chinese traditional medicine can improve the immune function of patients with advanced lung cancer， provides clinical evidence for TCM anticancer.