Objective By comparison with the Etoricoxib， observation Juanbilijieqing Fang in treatment of acute gouty arthritis clinical efficacy and effect on the main inflammatory factor. Methods The patients were randomly divided into two groups， the treatment group received Juanbilijieqing Fang treatment， control group with etoricoxib tablets intervention. we observe their changes include of swelling and pain， C-reactive protein（CRP）， erythrocyte sedimentation rate（ESR） and tumor necrosis factor-α（TNF-α）， serum interleukin-1β（IL-1β）， serum interleukin-6（IL-6）， and adverse effects. Results After one week of treatment， the symptoms and signs of the treatment group and the control group were significantly improved， and the control group was more obvious， the difference was statistically significant（P<0.05）， but the swelling’s total score were close to the two groups. After treatment， CRP and ESR were significantly improved（P<0.05）， and there was no significant difference between the two groups（P>0.05）. The serum levels of TNF-α， IL-1 and IL-6 were decreased in the two groups after treatment， and the treatment group was more obvious than the control group（P<0.05）. There was significant difference in the adverse reaction rate of the two groups（P<0.05）. Conclusion Juanbilijieqing Fang can effectively relieve acute gouty arthritis signs and symptoms， improve their CRP， ESR， inhibit the serum TNF-α， IL-1β， IL-6 expression. It is the treatment of acute gouty arthritis effective herbs and deserves widespread use and further study.