Objective To observe the effect of Yujin Ting granule on serum IL-8 AECOPD model rats， effects of TNF-alpha and CRP. Methods Divided 72 Wistar rats， randomLy divided into blank control group， model group， Yujin Ting granule low dose group， Yujin Ting granule medium dose group， Yujin Ting granule high-dose group， dexamethasone group. Using dexamethasone inhalation plus LPS lung perfusion of compound factors to establish the rat model of AECOPD. The application of Yujin Ting granule intervention. Scape of determination of serum IL-8 by the method of ELISA， TNF-and CRP containing alpha the amount of particles. Results The Yujin Ting granule group compared with the model group， the serum IL-8， TNF-alpha and CRP were statistically significant（P<0.05）. Conclusion Yujin Ting granule on serum IL-8 scape of rats with AECOPD， TNF-and CRP have a significant intervention effect， can effectively reduce IL-8， TNF-alpha and CRP level.