Objective The preliminary screening of antihypertension activity effective parts for Coreopsis tinctoria Nutt. Methods 30 healthy rabbits were randomly divided into normal control group， captopril group， Coreopsis tinctoria Nutt. Petroleum ether extraction parts group， the ethyl acetate extract group and n-butyl alcohol extraction and water parts group， ar vein injection， application BL-420F biological and functional experimental system logger observe the changes of arterial blood pressure of rabbits in each group. Results Compared with normal control group， Coreopsis tinctoria Nutt. the ethyl acetate extract group and n-butyl alcohol extraction， water parts group， rabbits were significantly lower systolic blood pressure（P<0.05）， the ethyl acetate extract group rabbit arterial diastolic blood pressure decreased very significantly（P<0.01）， and water parts group rabbit artery diastolic blood pressure has significant differences（P<0.05）. Conclusion Coreopsis tinctoria Nutt. the ethyl acetate extract group and n-butyl alcohol extraction and water parts group can make blood pressure was significantly decreased in rabbits.