Objective To explore the influence of Shenci capsule on lung adenocarcinoma A549/DDP multidrug resistance in nude mice. Methods Vaccinate 40 C57BL/6 mice with lung adenocarcinoma A549/DDP cell suspension and establish solid tumor model， randomly dividing into Shenci capsule team， Shenci capsule+cisplatin group， cisplatin group and comparison team. Control groups are given same amount of physiological saline and other groups of tumor-bearing mice offered medication 21d， adopt FQ-PCR technology to examine expressions of lung adenocarcinoma A549/DDP lung cancer tissues ERCC1 mRNA， RRM1mRNA， hMLH1mRNA， BRCA1mRNA. Results The results could reduce the expression of ERCC1， RRM1 and BRCA1 genes， and increase the expression of hMLH1mRNA gene. Conclusion Using multi-gene regulation to improve the cisplatin resistance state of lung adenocarcinoma A549/DDP in nude mice， it may be one of the methods of Shenci capsule reversing lung cancer multidrug resistance.