Objective Through exploring Taohe Chengqi decoction on chronic renal failure rats micro inflammatory factor influence， so as to clarify the Taohe Chengqi decoction in the treatment of CRF micro-inflammatory state mechanism. Methods 60 male SD rats， 7 weeks old， weighing 180～200g， were randomly assigned to normal group， sham operation group， model group， control group， treatment group， with 12 rats in each group. I n model group， control group and treatment group were treated with the 5/6 hysterectomy in animal models；sham operation group only double kidney is membrane peeling； blank group received no surgery. For 56 days consecutive to drugs after the operation， using ELISA method for detecting content of CRP and TNF-alpha， IL-6， ALB， and electron microscopic observation on the ultrastructure of kidney tissue. Results Taohe Chengqi decoction group reduce the content of micro inflammatory factor CRP， TNF-α， and IL-6， increase the content of ALB， reduce the degree of renal interstitial fibrosis. Conclusion Taohe Chengqi decoction improves micro-inflammatory state in chronic renal failure， delaying the development process of chronic renal failure.