Objective Establish the quality standards of kidney clear the granule. To better control the quality of the kidney clean the granule. Methods By thin layer chromatography（TLC）， the kidney pellet formula ingredients of astragalus membranaceus， dogwood， alisma， notoginseng for qualitative identification；Using high performance liquid chromatography（HPLC） method for kidney clear the granule characteristics of effective composition content of loganin horse money. Results Qualitative identify the contents of the TLC spots were clear， determine the content of three groups of agents loganin were 0.81 mg， 0.82 mg/g and 0.79 mg/g/g； System durability test， the specificity test， linear range， precision test， repeatability test， sample recovery rate test conform to the requirements. Conclusion This method is safe， reliable， and can be used for kidney clear quality control of the granule.