Objective To observe how the transcutaneous electrical acupoint stimulation effects on blood urea nitrogen（BUN）， lactate dehydrogenase（LDH）and creatine kinase isoenzyme（CK-MM）in college athletes. Methods 45 male college athletes were randomly divided into 3 groups， control group， treatment group 1 and treatment group 2， 15 people in each group. Each group were trained intensively for 2 weeks， treatment group 1 and treatment group 2 were treated respectively with TEAS one hour before exercise and one hour after exercise. The control group did not intervene. ， LDH， BUN and CK-MM levels were measured 24h before exercise and 24h after 2 weeks of exercise training in each group， respectively. Results Compared with the blood LDH， BUN and CK-MM levels of the athletes of control group before and after the experiment， there was very significant difference（P<0.01）. Compared with the blood BUN levels of the athletes of treatment group 1 and treatment group 2， there was no significant difference（P>0.05）. But the blood LDH and CK-MM levels of the athletes， there was significant difference（P<0.05）. After 2 weeks of training， the blood LDH， BUN and CK-MM levels of the treatment group 1 and 2 have significant differences compared with the control group（P<0.05）. Conclusion Transcutaneous electrical acupoint stimulation can effectively prevent the protein of body of large amount of exercise decomposing， protect skeletal muscle cell membrane permeability， reduce blood LDH， BUN and CK-MM levels， and prevent exercise-induced skeletal muscle micro injury.