Objective To investigate the relationship between the telomere length in peripheral white blood cells of methamphetamine addicts and TCM syndrome elements， thus exploring effects of methamphetamine on human health of TCM internal mechanism at the gene level. Methods All of the study participants are Han Chinese between the ages of 20 and 49， the experimental group is recruited from 136 cases of methamphetamine addicts and the control group is recruited from 200 cases healthy volunteers. Standard diagnostic information collection and using plain dialectical method of extracting features of TCM syndrome elements， and applying to QPCR based techniques for the measurement of peripheral blood leukocyte telomere length. Results （1）Correction for age and gender， the telomere length of methamphetamine group is shorter than that in the healthy group（P<0.05）. （2）The distribution of TCM syndrome elements of methamphetamine addicts： disease is mainly distributed in the liver， spleen and kidney， especially in liver most common； the most common case is Qi stagnation of excess syndrome； the most common case is Qi-deficiency of asthenia syndrome. （3） After adjusting the age and sex， there is significant difference（P<0.05） among the telomere length of formation of liver， wet and heat syndrome of methamphetamine group and telomere length of adjusted group is more shorter than that in the healthy group. Conclusion （1） Methamphetamine addicts will cause telomere damage in peripheral white blood cells and will make telomere length short. （2） Methamphetamine can cause organs dysfunction and disease is mainly in liver； Qi stagnation and Qi deficiency are the most prominent characteristics of disease leading to the methamphetamine addict. （3） The shortened of methamphetamine addicts telomere length is related to the formation of liver， wet and heat syndrome， and reveal the effects of methamphetamine on human health of TCM internal mechanism at the gene level.