Objective To observe the effects of Tuling Qiangen decoction in combination with Adefovir dipivoxil on patients with chronic hepatitis B. Methods Patients with chronic hepatitis B were randomly assigned to treatment group and control group. The treatment group was treated with Adefovir dipivoxil and Tuling Qiangen decoction concomitantly， the control group was treated with Adefovir dipivoxil only. The HBV-DNA levels and liver function parameters were determined before and after treatment. Results The above mentioned parameters of both groups in the post-treatment decreased， compared with those in the pro-treatment. The decrease in the treatment group was significantly superior to that in the control group after treatment（P<0.01）. The virus response rate in the treatment group was higher than that in the control group（P<0.05）. Conclusion Tuling Qiangen decoction in combination with Adefovir dipivoxil can stabilize liver function and inhibit the reproduction of HBV-DNA on patients with chronic hepatitis B.