MiRNA is the non-coding RNA which length about 20-24 nucleotides with the function of regulating， inhibiting mRNA translation to regulate the nearly 30% of all human protein encoding in the human body， it can regulate a variety of biological processes， including the organism growth， development and disease. Studies have indicated that miRNA plays an important role in the development of diabetes and its complications， and it has become a key factor in the regulation of biological processes. Diabetic ulcer is the most common complications of diabetes， there are amounts of evidences in the generating and healing process that miRNA counts a lot in the diabetic ulcer. In this paper， we overview of related miRNA function of nerve and vascular damage， and ulcer healing process in the pathogenesis of diabetic foot.