Objective To resarch the influence of Yishen Huazhuo method on learning and memory ability in dementia rats due to Multiple cerebral infarction. Methods Select the model of dementia rats due to multiple cerebral infarction， divided into the administration group， the model group and the false surgery group， give drug to the administration group 3 days in advance. Use water morris labyrinth to evaluate the rats’ cognitive， use the method of HE staining to evaluate the pathology results. Results ①In the training of the morris water labyrinth of misprision of platforms， At the third training， the three groups begin to vary， For the incubation period of escape， false operating team use the shortest time， and the administration group use more shorter time than the model group. The three groups use the same time in the Fifth Train， but the model group takes more times for learning. ②In the exploration temp， the false surgery group cross platform most times The number of treatment group across platforms significantly more than model group. Conclusion The method of Yishen Huazhuo can dramatically improve the dementia rats’ memory and learning ability.