Objective To observe the effectiveness of Chailong Jieyu pills on the improvement of anxiety symptoms and quality of life on patients with acute coronary syndrome（ACS） after the treatment of PCI. Methods There were a total of 60 cases of anxiety symptoms in patients with ACS after percutaneous coronary interventional therapy（PCI） assessed by Hamilton anxiety scale were divided by random and single-blind method into treatment group and control group， each group was treated with western medicine such as dual antiplatelet treatment， besides the western treatment， the treatment group was given Chailong Jieyu pills for 4 weeks. The Hamilton anxiety scales， SF-36 health survey scale scores were compared before and after the treatment. Results The Hamilton anxiety table scores of the two groups after the treatment were significantly decreased（P<0.05）， compared with the control group， the treatment group decreased significantly（P<0.05）； After the treatment， both groups’ SF-36 Health Survey Scale scores were significantly increased（P<0.05）， compared with the control group， the treatment group increased significantly （P<0.05）. Conclusion Chailong Jieyu pills can effectively improve the anxiety symptoms of ACS patients after PCI and improve the quality of life.