Objective To study the analgesic and anti-rheumatoid arthritis activities of compound Tongbi capsule（CTC）and its mechanism of anti-inflammatory. Methods Analgesic effects of CTC were evaluated by models of pain caused by acetic acid and hot plate. Models of auricle edema in mice， hind paw inflammation swelling， cotton pellet granuloma and Adjuvant Arthritis（AA）models in rats were used to detect the anti-rheumatoid arthritis activities. Level of PGE2 was determined by ELISA assay. Results The CTC had significant analgesic effects on the models of pain caused by hot plate and acetic acid. The CTC had an obviously inhibitory activity to hind paw inflammation swelling， granuloma hyperplasia and AA， but its activity on auricle edema wasn’t observed. Furthermore， it could also decrease the content of PGE2 in serum. Conclusion The compound Tongbi capsule had significant effects on analgesic and rheumatoid arthritis， which may be related to the inhibition of PGE2.