Objective Optimizing Ruanmailing granules pellet the best preparation for molding process. Methods Different proportion of the dry extract powder， dextrin and soluble starch respectively after granulating formability of granules， liquidity， the influence of the melt and particles percent of pass， optimize Ruanmailing granules pellet best excipient. Results Ruanmailing granules best excipient proportion to dry paste powder： dextrin soluble starch 4：1：2， plus 0.05% stevia sugar， 90% alcohol is right amount， the formability of particles， good liquidity， melt fraction particles is highest， In relative humidity（80±2）%， Temperature is（25±1）℃ is placed under the condition of 12 h， the moisture absorption rate below 6%. Conclusion Optimizing Ruanmailing granules pellet molding process is stable， scientific and reasonable， made by the particles tend to do well the indicators and comply with the “Chinese pharmacopoeia” and corresponding quality requirements of the granules.