The negative blood caused disease of fluid” the blood movement and blood overflow pulse mechanism for disease of fluid was described， the same as malignant pleural effusions， but lung spleen and kidney organs dysfunction， Yang is not warm， blood， fluid， Qi was phased each other as the disease. Based on this theory， the treatment of malignant pleural effusion for Warming Yang first， Qi， blood and fluid， were combined with treating fluid and blood， Qi regulating parallel， “negative blood”and “disease of fluid” ainto each other， would be grasped the blood， water and Qi dynamic balance.