Objective To observe the effects of Yishen Pinggan decoction on high blood pressure and endothelial function with some related indicators. Methods These 69 patients with Yang hyperactivity and Yin deficiency type of essential hypertension were randomly divided into 2 groups， combination of Chinese and western medication group（the Yishen Pinggan decoction and losartan potassium tablets）， western medicine control group（losartan potassium tablets）. Before and after 3-month treatment， the blood pressure and clinical symptoms were tested or measured. The expression of hs-CRP， ICAM-1， SDF-1 levels were measured by commercial ELISA kits. After the treatment， SPSS18. 0 statistical software was used to analysis the results. Results After three months of treatment， all the BP datas were decreased in control and treated group（P<0.05）， 24hSBP， 24hDBP， dSBP， dDBP， nSBP were decreased more in the treated group（P<0.05）， no significant difference in nDBP was found between control and treated group（P>0.05）， which indicates the antihypertensive effect of the treated group is superior to the control group. The endothelial damage relevant indicators were found improved in control and treated group（P<0.05）， hs-CRP， ICAM-1， SDF-1 were improved more in the treated group（P<0.05）. Conclusion Yishen Pinggan decoction could decrease blood pressure， improve the Endothelial function which was associated with the decreasing in the expression of hs-CRP， ICAM-1 and increasing in the expression of SDF-1.