Objective To observe the clinical effect and Security of Fufang Biejia Ruangan pills Lamivudine and Adefovir on portal hypertension in patients with liver cirrhosis. Methods The 94 patients with liver cirrhosis portal hypertension， were randomly divided into two groups： the observational group with 35 cases oraling Fufang Bijia Ruangan tablets， Lamivudine and Adefovir， and the control group 33 oraling only antiviral drugs. And the treatment lasted 12 monthes. The message of HBVDNA， PD， PVa， ALT， AST， PLT， LSM， CTP， Serum creatinine and Four urinary protein signs were recorded at baseline， 6th month， 12th month. Results Observational group was statistically significant than the control group in PD/PVa， FIB4， LSM， eGFR， IGU and α1M1（P<0.05）. But， in other hands， for example HBVDNA， CTP， TRU and MA， two groups was no significant difference（P>0.05）. Conclusion Fufang Bijia Ruangan tablets， being security， can improve Portal hemody namics by lightening Liver Fibrosis， reducing the diameter of portal vein， increasing Portal vein mean velocity， and can protecting the renal function.