Objective To establish the quality standard of Qidan Xiaoke Capsule. Methods Qualitative identification of Astragalus， Rhizoma Coptidis in the formula was carried out by thin-layer chromatography（TLC）. High performance liquid chromatography（HPLC） was used for the content of Salvianolic acid B in the preparation. Results TLC spots were clear and well-separated without negative interference， the line range of Salvianolic acid B was 0.2856～2.856μg， respectively， with good linear relationship with the peak area integral value（r=0.9996）， the average recovery rate was 99.55%， RSD was 0.965%. Conclusion The qualitative and quantitative method with good resolution and was simple， convinient and reliable with good precision， which can be used for the quality control of Qidan Xiaoke Capsule.