Objective To observe the clinical effect in Hyperplastic disease of breast（HDB）with the treatment of Scrapping along the distal meridians， and its impact on the blood perfusion of microcirculation. Methods 48 cases of HDB patients were divided into the treatment group and the control group randomly， the treatment group used the treatment of scrapping along the distal meridians， and the control group treat by acupuncture. To evaluate the patients’ symptoms and signs and the blood perfusion of microcirculation before and after treatment with the Color Ultrasonography and laser Doppler flowmeter. Results Both groups could effectively treat HDB， the blood perfusion of microcirculation of the treatment group was better than the control group（P<0.05）. Conclusion Scrapping along the distal meridians were effective on HDB clinically， and also could improve the blood perfusion of microcirculation.