Objective The study is to test the Buzhong Yiqi Pills intervene Qi-deficiency constitution. Methods We recruited the healthy Qi-deficiency constitution divided into control group and intervention group. We used the Buzhong Yiqi Pills intervene Qi-deficiency constitution for one month. Results Compared with the control group， the Qi-deficiency constitution transition scores of intervention group improved significantly after 1 month treatment. The other constitution scores in CCMQ changes， but no significant difference before and after treatment in the intervention group， while the scores in control group significantly changed in Yang-deficiency constitution， Yin-deficiency constitution， blood stasis constitution. Conclusion Buzhong Yiqi Pills can significantly improve the Qi-deficiency constitution.