Objective To observe the clinical effect of Wushi Youguiyin with acupuncture for premenopausal and postmenopausal disease with syndrome type of kidney yang deficiency. Methods In this study， 60 cases of Premenopausal and postmenopausal disease with syndrome type of kidney yang deficiency were digital randomly divided into 2 groups， including treatment group and control group. received acupuncture with traditional Chinese medicine of Wushi Youguiyin treatment group of 30 patients， recevied Climen orally group of 30 patients. The treatment covered 3 courses lasting 3 months. The changes of symptom scores were compared before and after treatment， clinical effect were evaluated. Results The total effective rate was 76.66％ in the treatment group， and was 74.19% in the control group， the difference bing not significant（P>0.05） in the control group and reatment group. Conclusion Acupuncture with traditional Chinese medicine of Wushi Youguiyin treatment can efectively improve the symptoms of menopause. This treatment meet the need of patients who refuse hormone replacement therapy Climen.