Objective To observe the clinical efficacy of Huanglian Jinxin Decoction to treat Perimenopausal syndrome. Methods 100 cases were selected and randomly divided into two groups：treatment group in which 50 cases were treated with Huanglian Jinxin Decoction and control group in which 50 cases were treated with Zhibai Dihuang Wan for 8 weeks， then the efficacy was observed. Results The total score of Kupperman score and the score of some item were significantly reduced after treatment， the treatment group showed better clinical efficacy than the control group（P<0.001）. Conclusion Huanglian Jinxin Decoction can significantly alleviate Symptoms of hot flushes and sweating， providing excellent efficacy. The method of clearing away the heart-fire and strengthening spleen may provide a new idea for the treatment of perimenopausal syndrome， which is worthy of further promotion and application.