Objective To explore the relationship between coagulation and inflammation index and erysipelas progress. Methods Collecting 58 cases of erysipelas patients（divided into reference group in acute stage 28 cases and chronic stage 30 cases） and 28 cases of healthy patients’ clinical data， including inflammation index and coagulation function， and analyzed the results. Results On the premise that the baseline data is comparable， there were significant statistical differences between the two groups in CRP， D-dimer， fibrinogen（P<0.05）. D-dimer and fibrinogen were higher than the normal range as a risk factor for the occurrence of erysipelas， prothrombin activity as a protective factor erysipelas occurrence. In acute phase and chronic phase group， the white blood cells， neutrophils， fibrinogen decreased， lymphocytes and D-dimer were increased in the chronic phase. Conclusions Serum CRP and D-dimer and other coagulation index plays an important role in erysipelas occurrence and development process. We should pay more attention to the coagulation detection in lower limb erysipelas.