Objective To meta-analyze the clinical curative effect and safety of multi-ways of using Chinese medicine combined with western medicine in the treatment of iver failure. Methods Searching related literatures from Pubmed， the Cochrane Library and database of CNKI， CBM， WANFANG， WEIPU from the time its built to January， 2017. Collect all randomized controlled clinical trials. Application of the Cochrane risk of bias assessment tool for literature methodology quality score was used. Using revman 5.3 methods in the system to analyze data. Results 23 researches were included. Meta analysis showed that： when compared with the control group， the multi-ways of using Chinese medicine combined with western medicine treated on liver failure was superior in the total effective rates and liver function， lower in the mortality， blood ammonia and endotoxin， between the two groups are significantly different（P<0.05）. Conclusion Using Chinese medicine in multi-ways combined with western medicine treated on liver failure is better than western medicine control group. However， considering about the low quality of studies included， we still need a large number of high-quality RCTs to test its efficacy and safety.