Objective To Observe Compound Lonicera and Forsythia Detoxification Mixture’s therapeutic effect on curing vesicular erysipelas. Methods Randomly dividing 120 erysipelas patients into a therapeutic group of 60 patients and a control group of 60 patients， treating the both groups with antibiotic， and on this basis， the therapeutic group is provided with oral Compound Lonicera and Forsythia Detoxification Mixture， observe the therapeutic effects of the both groups. Results The therapeutic group’s cure rate is superior to the control group（P<0.05）， and its decease healing period is obviously shorter than the control group， TSS ratio as well as the self-evaluation from its patients are both superior to the control group. Conclusion Compound Lonicera and Forsythia Detoxification Mixture has notable therapeutic effect on curing vesicular erysipelas， and is valuable for clinical application.