Objective To observe serum MCP-1， ICAM-1 levels and the therapeutic effect of Tangshenkang granules of diabetic kidney disease with Qi-Yin eficiency and blood stasis syndrome. Methods 66 cases of patients with Qi-Yin eficiency and blood stasis syndrome were randomly divided into treatment group and control group， the actual completion of 63 cases， 32 cases in treatment group， 31 cases in the control group； and a healthy normal group of 20 cases of patients was established. Two groups of patients were given Conventional hypoglycemic and antihypertensive therapy， in addition， Tangshenkang was plused in treating at treatment group and it was used three times a day， each time blunt one bag. The course of treatment was 8 weeks. The changes of clinical efficacy， urinary albumin/ urine creatinine（ACR）， serum MCP-1 and ICAM-1 levels were observed in two groups of patients. Results The total effective rate in treatment group was significantly better than the control group（P<0.01）. After treatment， the levels of ACR in treatment group and control group were significantly lower（P<0.01）， and the treatment group was better than control group（P<0.01）. Serum MCP-1 and ICAM-1 levels were significantly higher than those of the normal group（P<0.01）； after treatment， the treatment group and the control group can reduce the level of MCP-1 and ICAM-1（P<0.01）， the treatment group decreased were better than the control group（P<0.05）. Conclusion Tangshen can significantly improve the clinical symptoms and blood stasis in patients with DN， reduce urinary protein， serum MCP-1 and ICAM-1 levels， inhibition immune inflammatory response， can protect the kidney， delaying kidney disease course.