Objective To investigate the clinical effect of Ziwuliuzhu moxibustion treatment of enteral nutrition associated diarrhea of ICU patients. Methods To observe 146 cases of ICU patients with enteral nutrition in our hospital during October 2015~2016 year in February， According hospitalization time they were randomly divided into Ziwuliuzhu acupoints group（observation group） and conventional moxibustion treatment group（control group）. Observing the degree of diarrhea before and after treatment. Results The markedly effective rates of observation group and control group respectively were 90.67% and 69.01%. By the statistical test， P<0.05， the difference was statistically significant. Prompting that Ziwuliuzhu moxibustion clinical curative effect is obviously superior to conventional moxibustion. Conclusion The treatment of Ziwuliuzhu moxibustion of ICU patients with enteral nutrition associated diarrhea has significant curative effect.