Objective To prepare stutellarin Hydrophilic Matrices sustained release tablet， and to investigate its release characteristics in vitro. Methods Using hydroxypropyl methylcellulose（HPMC） as the matrix material. By L9（34） orthogonal design to study the best preparation technology of stutellarin Hydrophilie Matrices sustained release tablet；the assay of the release in vitro was valued by UV spectrophotometry with breviscapin as evaluating indicator. Results The optimum preparation conditions of stutellarin Hydrophilic Matrices sustained-release tablet were A2B1C3（The amount of HPMC was 45 mg， E4M HPMC was selected， filler dose of 182 mg）； the repeatability of three batches were good. Its release in vitro is similar with Higuchi release characteristics. Conclusion The preparation procedure of stutellarin Hydrophilic Matrices sustained-release tablet is feasible and repeatable. The tablets have obviously sustained property.