Objective To use TCM inheritance auxiliary system（TCMISS V1. 1） in the frequency statistics， association rules， correlation analysis， drug core combination analysis and unsupervised hierarchical clustering algorithm to obtain the entropy， traditional Chinese medicine in the treatment of diabetic foot washing prescription drugs， smoked core core combinations and new prescription. Results The statistics of the 95 prescriptions， the frequency of use of the top 10 are safflower， angelica， cassia twig， Caulis Spatholobi， radix paeoniae rubra， Rhizoma Chuanxiong， Radix cyathulae， lopseed， peachseed， huangqi. Combination of drugs use frequency from high to low ranking， the first 3 groups were “safflower Guizhi”， “angelica， safflower”， “safflower， Caulis Spatholobi”. And dig out the core combination of herbal fumigation and washing prescription for treating diabetic foot， 16 and 8 new prescriptions that may have clinical value. Conclusion The traditional Chinese medicine in the treatment of diabetic foot fumigation in Huoxue Zhitong， Shujin Tongluo medicine， and through data mining initially explored the main drug fumigation of Chinese medicine prescription composition：Angelica， safflower， astragalus， Guizhi， Rhizoma Chuanxiong， radix paeoniae rubra， lopseed， walnuts， milk incense， myrrh， Caulis Spatholobi. Cyathula etc.. The clinical value of the new method can be further explored according to different syndrome types.