Objective Four kinds of Traditional Chinese Medicine Injections（TCMIs） including Qingkailing， Danshen， Shuanghuanglian， Dengzhanxixin rich in macromolecules were investigated to find their potential toxicity， and to prove that macromolecular substances was one of the most important causes. Methods Four injections rich in macromolecules（≧10 k） were prepared with molecular sieves. Rabbits were randomly divided into blank control group， original injection group， and injection rich in macromolecule group. Rabbits’ temperature was recoded with an ultra-red ear thermometer， and their weight was also measured， before and 2 hours after intravenous administration every day. Intravenous administration was arranged once a day for 5 days. Then， 3 animals in every group were sacrificed， and their blood and organs were collected. Routine blood test， blood biochemistry assay， organ coefficient， body temperature， weight， and pathological investigation were made. The remaining animals without administration were used to observe recovery for additional 5 days. Results The results of blood tests showed that， in injections rich in macromolecules groups administrated for 5 days， some values of blood routine test（white blood cell， granulocyte， and platelet）and blood biochemical assay （GPT and GOP） increased to some extent；rabbit’s weight decreased；body temperature increased；some injuries were found in liver and kidney tissue. However， the abnormal value or injueries recovered to some textent. Conclusion The results suggested that， macromolecular substances were harmful for liver and kidney function in rabbit.