Objective To study the effects of Xiaoshuan Decoction（XSD） on the VEGF and VEGFR-1 in Traumatic Deep Vein Thrombosis in Model Rabbits. Methods 45 SPF male New Zealand white rabbits were adaptively fed for one week later， Randomly selected 27 rabbits. The successfully established rabbits were randomly divided into 3 groups： XSD group（group A）， low molecular weight heparin（LMWH） group（group B）， model control group（group C）， the remaining 18 rabbits were randomly divided into D and F groups， namely the sham operation group， the blank control group，9 of each group. Each group received continuous administration for one week， and the expression level of VEGF and VEGFR-1 was tested at different time points. Results XSD group， LMWH group and model control group showed the expression level of VEGF and VEGFR-1 was increased gradually by 1d to 7d. XSD group and LMWH group showed higher level of VEGF and VEGFR-1 than the model control group over the same period， with statistical significance（P<0.05）. The difference on VEGF and VEGFR-1 between the XSD group and LMWH group showed no statistical significance（P>0.05）. Conclusion In deep vein thrombosis， VEGF and VEGFR-1 are clearly expressed， and anticoagulant therapy can promote the function， XSD can promote the expression of VEGF and VEGFR-1， increases the permeability of blood vessels， and can effectively prevent the formation of lower extremity DVT. Its action mechanism may be similar to LMWH.