Objective To observe the difference of relieving fever effect on feverish rats to similar prescriptions of Coptis chinensis and Evodiae rutaecarpa. Methods Compounded 15% liquid of the Dride Yeast was injected into the rats by the means of back hypodermic injection， respectively. After 4.0 hours， the rats were orally adiministered immediately with Coptis， Evodia， Zuojinwan， Ganlusan， Zhuyuwan， Anti-Zuojinwan and Acenterine， respectively. Temperature change of the groups of the rats was surveyed and recorded in 0.5h， 1.0h， 2.0h， 3.0h and 4.0h. Results Zuojinwan can restrain obviously temperature of rats raising， and Ganlusan secondly. There were no apparent effect of control for Coptis， Evodia， Zhuyuwan， Anti- Zuojinwan. Conclusion The difference of relieving fever on the rats is very obviously for the series of similar prescriptions of compatibility， but it is storngest temperature raising of rats obviously.