Objective To observe the clinical effect of proximal fibular osteotomy combined with Danzi Kangxi Granules in treating osteoarthritis of the knee. Methods 60 patients with osteoarthritis of the knee were randomly divided into control group and treatment group（n=30）. The control group underwent proximal fibula osteotomy， postoperative routine use of detumescence， anti-inflammatory and analgesic drugs and topical therapy. The treatment group was treated with Chinese herbal compound danzikangxi granules orally started on the basis of the control group on the second day after surgery， 1 week for 1 course. 2 groups were treated for 1 course. 3 weeks after operation， the VAS score， JOA joint function score and clinical efficacy were compared between the 2 groups. Results After 3 weeks， the VAS score and JOA joint function score of the treatment group were significantly higher than those of the control group， the clinical effective rate was significantly higher than that of the control group， the difference was statistically significant（P<0.05）. Conclusion The Danzi Kangxi granules can effectively relieve the knee joint pain， swelling and dysfunction and improve the joint function score.