Objective To observe the clinical effect of essence Jinggubugu granule on senile osteoporosis. Methods 60 cases of male elderly patients with osteoporosis were randomly divided into treatment group and control group with 30 cases in each group， the treatment group received Jinggubugu granule orally once a day， the control group treated with Xianlinggubao capsule 2 times daily， 3 capsules each time， to observe the clinical efficacy of the treatment after 6 months. Bone pain and bone mineral density were used as observation indexes， and the curative effect of TCM syndrome after treatment was evaluated. Results the total effective rate of the treatment group was 93.3%， which was significantly higher than that of the control group 73.3%. Conclusion Jinggubugu granule has good effect on senile osteoporosis.