Objective To lower numb taste of Bulleyaconitine A and slower the release of Bulleyaconitine A in the body. Methods Encapsulation of Bulleyaconitine A was done by ionic polymer and the optimal condition was obtained by orthogonal experimental design. Results The optimal condition is 0.43%（w/w） Bulleyaconitine A、 99.9% alcohol、 stirring 20min、 12%（w/w） polyacrylic resin II. After 2 hours， the cumulative release rate of Bulleyaconitine A was lower 2% when pH4.0 buffer and water were used as solvent， respectively. While the cumulative release rate of Bulleyaconitine A reached 43% when pH6.8 buffer was used as solvent. Conclusion Polymer encapsulation of Bulleyaconitine A is an effective way to lower numb taste of Bulleyaconitine A and it shows good reference on the application of tablets and oral fast dissolving films.