Objective The purpose of this study was to explore the effects of traditional Chinese medicine composition（TCMC）on inflammatory reaction of diabetic atherosclerotic rabbit modle by interventing p38mitogen-acti–vatedproteinkinase（p38MAPK） signal pathway. Methods DA rabbits were established by alloxan intravenous injection with abdominal aorta intima balloon injury， then intervened by TCMC of high， medium， low dose or simvastatin respectively. Rusults The expression of p38MAPK in the combination of high， medium， low dose and simvastatin group was reduced， and the difference was statistically significant（P<0.01）. The high dose group and simvastatin group had lower effects on hs-CRP， IL-6， TNF-α， ET， ICAM-1， VCAM-1 and the difference was statistically significant（P<0.01）. The medium dose group can reduce hs-CRP， IL-6， TNF-α， ET， VCAM-1 and the comparison of the model group is statistically significant（P<0.01）. The low-dose group decreased hs-CRP， and the difference was statistically significant（P<0.05）. The high and medium-dose group of TCMC had reduced the FBG， GHB and GSP of the diabetic arteriosclerosis rabbits， significantly lower than the model group（P<0.01）. The low-dose group of TCMC had a reduced effect on FBG， which was significantly lower than that in the model group（P<0.05）. There was no statistically significant difference between simvastatin group and model groups（P>0.05）. Conclution The traditional Chinese medicine composition may be able to inhibit inflammatory reaction of atherosclerotic rabbit modle by interventing p38mitogen-acti–vatedproteinkinase（p38MAPK） signal pathway.