Objective To analyze the effect of Traditional Chinese Medicine（TCM） in treating with HIV/AIDS at the period of ⅡA， ⅡB and Ⅲ. Methods To collect the HIV/AIDS subjects who were treated with TCM in the medical institutions of Yunnan province. One group（TCM group） took Fuzheng Kangdu decoction or Kangaibaosheng decoction orally. The other group（TCM combined HAART group， TCM group） took the decoctions but accepted the treatment of HAART as well. To compare the index before and after treatment. Results 1373 subjects totally. After treatment the scores of signs and symptoms were decreased significantly or maintaining stability in two groups. Compared with pre-treatment， the Karnovsky score maintain stability or increased significantly in two groups. After treatment， CD4 count in TCM group was decreased at the period of ⅡA but increased significantly or maintaining stability at the ⅡB in two groups. HIV-RNA load was decreased significantly or maintaining stability. The index about security showed that there wasn’t any difference before and after treatment. Conclusion The TCM effect the signs and symptoms and improve the quality of life. It can maintain or raise the CD4 count at the period of ⅡB and Ⅲ， and descend the count at ⅡA. The TCM may delay the infection course at ⅡA. It may be worth exploring the treatment combine TCM and HAART in the future.