Objective To investigate the correlation of NLR and CRP in treating HAP patients with Reduning injection before and after therapy. Methods One hundred HAP patients were enrolled. Peripheral blood of White blood count（WBC） and classification detection and CRP test were performed before and after therapy. Results （1） It was more common in the men aged （average age was 70. 74±15. 00 years old， male-female ratio was 71 to 29）. （2） Peripheral blood of WBC， neutrophil count（NC）， 1ymphocyte count（LC）， neutrophil-to-lymphcyte ratio（NLR） and C-reactive Protein（CRP） in hospital-acquired pneumonia patients were significant difference before and after therapy（all P<0.05）. （3） Spearman or Pearson correlation analysis showed that NLR had positive correlation with CRP（r or rs=0.538， P<0.01）. Conclusion Reduning injection could treat HAP patients effectively after therapy， which reflected it could lower pulmonary inflammation of the patients， and the positive correlation of NLR and CRP could further illustrate the key to the therapy.