Objective Evaluation on clinical efficacy and safety of heatclearing and pathogenicexpelling method based on theory of latent pathogen in the treatment of patients with allergic rhinitis. Methods A total of 120 patients with allergic rhinitis were randomly divided into three groups： traditional Chinese medicine（TCM） group treated with heatclearing and pathogenicexpelling method（200mL/times， 2 times/D）， western medicine group with Desloratadine Citrate Disodium Tablets（8.8mg/times， 1 times/D）， and integrated Chinese and western medicine group with heatclearing and pathogenicexpelling method combined with Desloratadine Citrate Disodium Tablets， Each treatment group was treated with continuous 1W for 1 courses， a total of 3 courses of treatment， each interval of 2D.40 cases in each group. Allergic rhinitis symptom score（ARSS） and quality of life score（QOLS） before， immediately after treatment， and after 1-year follow-up were compared among the three groups； and the recurrence rates and clinical safety were observed in all groups. Results After treatment， ARSS and QOLS decreased notably in all groups compared with those before treatment（P<0.01）. After the end of follow-up， the ARSS and QOLS in western medicine group showed insignificant differences compared with those before treatment（P>0.05）， but were evidently higher than those in TCM group and integrated Chinese and western medicine group（P<0.01）. The scores also decreased prominently in TCM group and integrated Chinese and western medicine group（P<0.01）， but the difference was not significant between these two groups（P>0.05）. There was insignificant difference among the three groups in the recurrence rate within 3 months（P>0.05）. The recurrence rate was notably lower in both TCM group and integrated Chinese and western medicine group than in western medicine group（P<0.01） 3 months later； however there was insignificant difference between TCM group and integrated Chinese and western medicine group（P>0.05）. No obvious trial related adverse reactions were observed in the three groups. Conclusion Both TCM of heatclearing and pathogenicexpelling method based on latent pathogen theory and Desloratadine Citrate Disodium Tablets can effectively improve the ARSS and QOLS. In terms of long-term clinical efficacy and recurrence rate improvement， TCM of heatclearing and pathogenicexpelling method is superior to Desloratadine Citrate Disodium Tablets， with greater clinical safety.