Objective To observe the clinical effect of combined chinese medicine foot bath and Zicui Juanbi Decoction in the treatment of diabetic peripheral neuropathy（DPN）. Methods One hundred and thirty two cases with DPN were randomized into four groups（Control group， Treatment group 1， Treatment group 2 and Treatment group 3， 33 cases in each groups）， and treated by respective medthods for eight weeks. The clinical efficacy， Toronto clinical scoring system（TCSS）， blood glucose， velocity of dorsal pedal artery and Nerve conduction velocity were observed before and after treatment. Results ① The clinical effective rate was 45.5%， 80.6%， 75. 0% and 90.0% respectively in control group， treatment group 1， treatment group 2 and treatment group 3， with higher rate in treatment group 1 and 3 than in the control group. ② After treatment， the TCSS were significantly lowered in four groups（P<0.01）， the TCSS was lower in the Treatment group 3 than in the control group（P<0.01）， and lower than in treatment group 1 and group 2（P<0.05）. ③ After treatment， the levels of blood glucose（FPG， 2hPG） were reduced in treatment group 1 and treatment group 3（P<0.05， P<0.01）， with lower level in the in treatment group 1 and group 3 than in the control group（P<0.05）. ④ After treatment， The velocity of dorsal pedal artery in the latter group was increased（P<0.01）， with higher velocity in treatment group 1 and group 2 than in the control group（P<0.05）， and with significant higher velocity in treatment group 3 than in the control group（P<0.01）. ⑤ After treatment， The MCV of the tibial nerve and SCV of the superficial peroneal nerve were increased in four groups（P<0.05， P<0.01）， with significant higher velocity in treatment group 3 than in the control group（P<0.01）， and the MCV of the tibial nerve in treatment group 3 was higher than treatment group 1 and 2. Conclusion Combined chinese medicine foot bath and Zicui Juanbi Decoction is quite effective against diabetic peripheral neuropathy in relieving clinical symptoms， peripheral hemodynamics and nerve conduction velocity.