Objective To summarize frequency distribution of the main diseases， syndromes（syndrome types and symptom factors）and syndrome characteristics of Traditional Chinese Medicine（TCM） clinical research based on TCM clinical research literatures of that published in journals nearly ten years. It provides the data support for the standardization construction of TCM terminology and the follow-up diagnostic standard of TCM. Methods We searched TCM clinical research literatures published from January 2007 to June 2016 from CNKI and VIP databases， and performed frequency statistics on the basis of standardized organizing TCM name of diseases， western medical name of diseases， syndrome types， syndromes and symptom factors. Results 9730 TCM clinical research literatures were totally included. Hot spot in clinical research of TCM according to frequency statistics from big to small， the top 10 TCM diseases ranking in sequence were chest impediment， edema， dizziness， and so on； the top 10 western medicine diseases ranking in sequence were coronary heart disease， non-insulin dependent diabetes mellitus， hypertension， and so on. The syndrome types of TCM in sequence were syndrome of dual deficiency of Qi and Yin， liver-kidney yin deficiency syndrome， syndrome of Qi deficiency with blood stasis， and so on. The symptom factors in sequence were Qi deficiency， blood stasis， heat， and so on. The syndromes of TCM in sequence were thread pulse， white fur， stringy pulse， and so on. Conclusion At present， the clinical syndromes of TCM are more complicated syndrome type， but less single syndrome type； in the list of syndrome factors in syndrome factor differentiation can cover the clinical research of Chinese medicine， and can avoid the problem of syndrome type of TCM are not unified， to hold the guiding role of TCM complex of syndrome differentiation and make it easier to be mastered； Syndrome differentiation of Clinical TCM will examine the tongue and pulse.