Objective To observe the effect of acupuncture at “Baihui five” combined with bloodletting therapy in the treatment of post-stroke depression clinical efficacy. Methods 76 patients with post-stroke depression were randomly divided into treatment group and control group with 38 cases in each group， the treatment group was given acupuncture at “Baihui five” combined with bloodletting therapy， the control group was treated with Western medicine. The Hamilton Depression Rating Scale（HAMD） score， neurological deficit scale score， Barthel index score and clinical efficacy were observed in the two groups. Results the two groups after treatment HAMD score and neurological deficit scale scores were significantly lower than before treatment（P<0.05）， the treatment group after treatment HAMD score， neural function defect scale score lowered more significantly than control group（P<0.05）； the two groups after treatment Barthel score was significantly higher than that before treatment（P<0.05）， the treatment group after treatment Barthel score increased more significantly than the control group（P<0.05）； the two group clinical total effective rate， total effective rate of the treatment group than the control group， the difference was statistically significant （P<0.05）. Conclusion Acupuncture “Baihui five”combined with the effect of bloodletting therapy in the treatment of depression significantly after stroke， better than pure western medicine treatment.