Objective To observe the clinical effects of Wenyang Jiedu（WYJD） formula with TACE on advanced primary hepatic carcinoma（PHC）， and explore the treatment model of integrated Chinese and Western medicines for advanced PHC. Methods 80 advanced PHC patients were randomly divided into control group and treatment group after TACE. The treatment group was treated with WYJD formula， while the control group with nothing. Clinical effects， survival time， liver function， APF， KPS scores， tumor recurrence and metastasis were detected. Results There were no significant differences in remission rate， stability rate and survival rate between treatment group and control group（P>0.05）. The median survival time of treatment group and control group were 10 months and 7 months， respectively. Liver functions were improved， AFP value significantly decreased， KPS scores significantly increased， and metastasis was better in treatment group（P<0.05）. Conclusion WYJD formula had a good effect on advanced PHC， especially on inhibiting liver metastasis. The study provided an experimental basis for integrated Chinese and Western medicines of PHC.