Objective To explore clinical effect of Yiliu decotion combined with laparoscopic resection in the treatment of thyroid cancer. Methods From January 2008 to January 2013 in our hospital a total of 84 cases of thyroid cancer patients， 50 cases were randomly divided into observation group and the control group of 34 patients， two patients underwent laparoscopic resection of thyroid tumors， the observation group plus patients in our hospital since the proposed prescriptions were observed after 1 month of treatment， and patients before and after treatment thyroglobulin（TG） level changes. Results The patients in the control group the total effective rate was 70.59% in the observation group， the total effective rate was 92%， with significant differences between the two groups（P<0.05）； the TG level， the patients in observation group after treatment than before treatment（P<0.05） decreased significantly after treatment， patients in the observation group were significantly lower after treatment of patients in the control group（P<0.05）. Conclusion Yiliu decotion combined with Laparoscopic resection in the treatment of thyroid cancer can significantly improve the efficacy of patients， while patients can significantly reduce serum TG levels， thereby reducing the recurrence rate of the tumor， it is worth promoting the use of clinical.